Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline
Abstract Background Tigecycline is a tetracycline derivative that constitutes one of the last-resort antibiotics used clinically to treat infections caused by both multiple drug-resistant (MDR) Gram-negative and Gram-positive bacteria.Resistance to this drug is often caused by chromosome-encoding mechanisms including over-expression of efflux pumps